Girolami A, Patrassi G, Cappellato G, Quaino V
Blut. 1980 Jul;41(1):61-6. doi: 10.1007/BF01039877.
Prothrombin was assayed in 24 patients with liver cirrhosis both as activity and as antigen. Prothrombin was found to be decreased by all methods and a good correlation was found among the three methods used. The serum prothrombin assay by means of the electroimmunoassay showed levels comparable to those observed in plasma, as expected. In the bidimensional electrophoresis system, plasma prothrombin appeared decreased but showed a normal mobility. Serum prothrombin in the same system showed the presence of three normal albeit reduced peaks or precipitates.
对24例肝硬化患者的凝血酶原进行了活性和抗原检测。结果发现，所有检测方法均显示凝血酶原水平降低，且所采用的三种方法之间具有良好的相关性。正如预期的那样，采用电免疫分析法检测血清凝血酶原的水平与血浆中观察到的水平相当。在双向电泳系统中，血浆凝血酶原水平似乎降低，但迁移率正常。同一系统中的血清凝血酶原显示出三个正常但峰或沉淀减少的情况。
