Averbeck D
Bull Cancer. 1980;67(3):245-54.
Rad-equivalences were established for four mono- and bifunctional furocoumarins, two of them of therapeutical interest. Using an eucaryotic cell system (Saccharomyces cerevisiae) rad-equivalences were determined for lethal effects, the induction of mutations and of intra- and intergenic recombination. For each furocoumarin the rad-equivalences for the genetic effects lay in the same range except those for the induction of intergenic recombination which gave higher values. Based on data obtained on mammalian cells in culture a rad-equivalence could be estimated for the phototoxic effect (cell killing effect) of 8-methoxypsoralen used in PUVA-therapy.
已确定了四种单功能和双功能呋喃香豆素的辐射当量，其中两种具有治疗意义。使用真核细胞系统（酿酒酵母）确定了致死效应、突变诱导以及基因内和基因间重组的辐射当量。对于每种呋喃香豆素，除了基因间重组诱导的辐射当量较高外，遗传效应的辐射当量处于相同范围。根据在培养的哺乳动物细胞上获得的数据，可以估算出用于光化学疗法的8-甲氧基补骨脂素的光毒性效应（细胞杀伤效应）的辐射当量。
