Dequeker J, Stevens E, Wuyts L
Curr Med Res Opin. 1980;6(9):589-92. doi: 10.1185/03007998009109493.
The anti-inflammamtory effectiveness and side-effects of magnesium dithiosalicylate were compared to aspirin in a 3-month, parallel, double-blind trial in 40 patients suffering from active rheumatoid arthritis. The results showed that 3 g magnesium dithiosalicylate daily had anti-inflammatory properties similar to those of 3 g aspirin daily in rheumatoid arthritis. A statistically significant change in morning stiffness, number of tender joints, pain score and erythrocyte sedimentation rate was observed in the magnesium dithiosalicylate group. In the magnesium dithiosalicylate group, 8 patients had to be withdrawn from the trial because of serious side-effects compared to 5 in the aspirin group. Gastro-intestinal intolerance occurred as frequently in both treatment groups. Hypersensitivity to magnesium dithiosalicylate was a serious problem and the reason for withdrawal in 4 cases. The high frequency of side-effects to magnesium dithiosalicylate makes this drug unacceptable for treatment of rheumatoid arthritis at the present time. Further pharmacological studies might reveal new derivatives which are as effective but with less side-effects. The anti-inflammatory activity of magnesium dithiosalicylate resembled that observed with gold and penicillamine. The fact that all these drugs have a sulphhydril group in common is stressed.
在一项针对40例活动性类风湿性关节炎患者的为期3个月的平行双盲试验中，对二硫代水杨酸镁的抗炎效果和副作用与阿司匹林进行了比较。结果表明，每日3克二硫代水杨酸镁在类风湿性关节炎中的抗炎特性与每日3克阿司匹林相似。在二硫代水杨酸镁组中，观察到晨僵、压痛关节数、疼痛评分和红细胞沉降率有统计学上的显著变化。在二硫代水杨酸镁组中，有8名患者因严重副作用而不得不退出试验，而阿司匹林组为5名。两个治疗组中胃肠道不耐受的发生频率相同。对二硫代水杨酸镁过敏是一个严重问题，也是4例患者退出试验的原因。二硫代水杨酸镁副作用的高发生率使得该药物目前不适合用于治疗类风湿性关节炎。进一步的药理学研究可能会发现新的衍生物，它们同样有效但副作用更少。二硫代水杨酸镁的抗炎活性与金制剂和青霉胺相似。强调了所有这些药物都含有巯基这一事实。
