Hess H, Mietaschk A, Ingrisch H
Dtsch Med Wochenschr. 1980 May 30;105(22):787-91. doi: 10.1055/s-2008-1070752.
Acute and subacute arterial occlusions of between 4.5 and 29 cm long could be dissolved in 11 patients by infiltration of small amounts (4000 to 110 000 U) of streptokinase or urokinase directly into the thrombus using a catheter. Use of a Grüntzig catheter enabled dilatation of possible stenoses during the same session. In 3 femoro-popliteal obliterations where lysis and catheter dilatation did not lead to sufficiently patent lumina occlusion recurred. In 3 patients with wide-ranging obliteration of the femoral, popliteal and almost all the arteries of the calf almost complete revascularisation could be achieved. Only transient slight side effects of lysis and coagulation disturbances were observed systemically. For prophylaxis of reobliteration platelet aggregation inhibitors are given for pre- and long-term aftercare.
通过使用导管将少量（4000至110000单位）链激酶或尿激酶直接注入血栓，11例患者4.5至29厘米长的急性和亚急性动脉闭塞得以溶解。在同一次治疗中，使用Grüntzig导管可对可能存在的狭窄进行扩张。在3例股腘动脉闭塞病例中，溶栓和导管扩张未能使管腔充分通畅，闭塞复发。在3例股动脉、腘动脉以及小腿几乎所有动脉广泛闭塞的患者中，几乎实现了完全血管再通。全身仅观察到溶栓和凝血紊乱的短暂轻微副作用。为预防再闭塞，在术前和长期后续护理中均给予血小板聚集抑制剂。
