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[正常及心肌缺血情况下放射性氯化铊(201TlCl3)从血液到心肌组织的转运动力学]

[Kinetics of radioactive thallium chloride (201TlCl3) transport from the blood to myocardial tissue normally and in cardiac ischemia].

作者信息

Ginzburg E M, Serebriakova L I, Mazaev A V, Eventov A Z, Bankuzov V A

出版信息

Kardiologiia. 1980 Aug;20(8):97-9.

PMID:6997589
Abstract

Extraction of 201TlCl3 diffusing into the heart tissue under conditions of its normal functioning and in the presence of ischemia was appraised on a model with isolated coronary perfusion of the myocardium by the dual-tracer method. From analysis of the discharge curve of the tracers used it is concluded whether or not microcirculation of the perfused area of the heart is uniform or heterogeneous. It was established that in myocardial ischemia, 201TlCl3 does not accumulate in the interstitium, which makes it possible to evaluate the zones with diminished inclusion of 201TlCl3 encountered in scanning of the heart as corresponding to diminished blood supply.

摘要

在心肌正常功能状态和存在局部缺血的情况下,利用双示踪剂法在离体心肌冠状动脉灌注模型上评估了扩散到心脏组织中的氯化铊-201((^{201}TlCl_3))的摄取情况。通过对所使用示踪剂的排出曲线进行分析,可得出心脏灌注区域的微循环是均匀还是不均匀的结论。已证实,在心肌局部缺血时,(^{201}TlCl_3)不会在间质中蓄积,这使得在心脏扫描中遇到的(^{201}TlCl_3)摄取减少的区域可被评估为对应于供血减少的区域。

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