Messick J, Spielman W S, Knox F G
Mayo Clin Proc. 1980 Oct;55(10):619-22.
We used very high doses of a competitive inhibitor of angiotensin II to investigate the role of the intrarenal renin-angiotensin system in the autoregulation of renal blood flow. Studies were carried out in dogs in which the renin and prostaglandin systems were suppressed. The results of our studies indicate that angiotensin II is not a prime mediator of the autoregulation of renal blood flow in response to reduced perfusion pressure.
我们使用高剂量的血管紧张素II竞争性抑制剂来研究肾内肾素-血管紧张素系统在肾血流自身调节中的作用。研究在肾素和前列腺素系统受到抑制的犬类中进行。我们的研究结果表明，血管紧张素II并非肾血流自身调节以应对灌注压降低的主要介质。
