Kamen B A, Bertino J R
Antibiot Chemother (1971). 1980;28:62-7. doi: 10.1159/000386061.
The transport of folate by murine leukemia cells, hepatic cells, choroid plexus and intestine is a complicated process involving at least two different carrier-mediated processes and/or passive diffusion by certain cells. Although there are marked similarities between many of the models studied, there are also striking differences, especially with regards to specificity of the transport system. This review compares and contrasts these different systems as well as briefly examining the role of folate binders and newer techniques for studying folate and anti-folate delivery to cells.
小鼠白血病细胞、肝细胞、脉络丛和肠道对叶酸的转运是一个复杂的过程，至少涉及两种不同的载体介导过程和/或某些细胞的被动扩散。尽管所研究的许多模型之间有明显的相似之处，但也存在显著差异，尤其是在转运系统的特异性方面。这篇综述比较并对比了这些不同的系统，并简要探讨了叶酸结合蛋白的作用以及研究叶酸和抗叶酸向细胞递送的新技术。
