顶体蛋白酶（顶体素）抑制剂：人尿胰蛋白酶抑制剂（UTI）和4-（2-羧乙基）苯基反式4-氨甲基环己烷羧酸盐盐酸盐（DV-1006）。
Inhibitors of the acrosomal proteinase acrosin: human urinary trypsin inhibitor (UTI) and 4-(2-carboxyethyl) phenyl trans 4-aminomethylcyclohexanecarboxylate hydrochloride (DV-1006).
作者信息
Sumi H, Toki N
出版信息
Experientia. 1980 Sep 15;36(9):1103-4. doi: 10.1007/BF01965994.
PMID:6998719
Abstract
Human urinary trypsin inhibitor (UTI) and (4-(2-carboxyethyl) phenyl trans 4-aminoethylcyclohexanecarboxylate hydrochloride (DV-1006) competitively inhibited the human acrosomal proteinase acrosin; Ki values were 1.2 x 10-8 M and 9.4 x 10-7, respectively.
摘要
人尿胰蛋白酶抑制剂（UTI）和4-（2-羧乙基）苯基反式4-氨基乙基环己烷羧酸盐酸盐（DV-1006）竞争性抑制人顶体蛋白酶顶体素；Ki值分别为1.2×10^-8 M和9.4×10^-7。
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Inhibitors of the acrosomal proteinase acrosin: human urinary trypsin inhibitor (UTI) and 4-(2-carboxyethyl) phenyl trans 4-aminomethylcyclohexanecarboxylate hydrochloride (DV-1006).顶体蛋白酶（顶体素）抑制剂：人尿胰蛋白酶抑制剂（UTI）和4-（2-羧乙基）苯基反式4-氨甲基环己烷羧酸盐盐酸盐（DV-1006）。
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本文引用的文献
1
The determination of enzyme inhibitor constants.酶抑制剂常数的测定
Biochem J. 1953 Aug;55(1):170-1. doi: 10.1042/bj0550170.
2
Leupeptin and antipain. Strong competitive inhibitors of sperm acrosomal proteinase (boar acrosin) and kallikreins from porcine organs (pancreas, submand. glands, urine).
Hoppe Seylers Z Physiol Chem. 1973 Oct-Nov;354(10-11):1304-6. doi: 10.1515/bchm2.1973.354.2.1304.
3
Acrosomal proteinase and proteinase inhibitor of human spermatozoa.人类精子的顶体蛋白酶和蛋白酶抑制剂
Science. 1972 Aug 25;177(4050):702-3. doi: 10.1126/science.177.4050.702.
4
Inhibitory effects of -amino acid esters on trypsin, plasmin, plasma kallikrein and thrombin.α-氨基酸酯对胰蛋白酶、纤溶酶、血浆激肽释放酶和凝血酶的抑制作用。
Biochim Biophys Acta. 1971 Jul 21;242(1):203-8. doi: 10.1016/0005-2744(71)90100-8.
5
Studies on human urinary trypsin inhibitor. 1. Its modification on treatment of urine with acid.人尿胰蛋白酶抑制剂的研究。1. 酸处理尿液对其的影响。
Thromb Res. 1977 Dec;11(6):747-54. doi: 10.1016/0049-3848(77)90103-7.
6
[Trypsin inhibitors in human urine (author's transl)].
Nihon Seirigaku Zasshi. 1977 Mar;39(3):53-8.
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