MacKeen D L
Int Ophthalmol Clin. 1980 Fall;20(3):79-92.
The development of ocular drug delivery systems has progressed greatly during the past four decades. This has resulted from better understanding of the pertinent physiological processes and from the availability of new synthetic polymers. More must be learned about the distribution of polymer solutions during the blink and their interactions with biosurfaces. In addition, awareness of the limitations placed on vehicle characteristics (e.g., viscosity, surface activity) by the variation in human eyes and more accurate extrapolation of data from relatively uncomplicated experimental models to the human eye will result in the development of even more effective ophthalmic vehicles designed for specific purposes and for particular drugs.
在过去的四十年里，眼部给药系统有了很大的发展。这得益于对相关生理过程的深入理解以及新型合成聚合物的出现。关于聚合物溶液在眨眼过程中的分布及其与生物表面的相互作用，还有很多需要了解的地方。此外，认识到人类眼睛的差异对载体特性（如粘度、表面活性）的限制，以及从相对简单的实验模型到人类眼睛更准确地外推数据，将导致开发出更有效的针对特定目的和特定药物的眼科载体。
