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通过紫外分光光度法研究氯丙嗪与有机溶剂和脂肪酸的相互作用。

Interaction of chlorpromazine with organic solvents and fatty acids as studied by UV-spectrophotometry.

作者信息

Bickel M H, Römer J

出版信息

Experientia. 1978 Aug 15;34(8):1047-9. doi: 10.1007/BF01915339.

DOI:10.1007/BF01915339
PMID:700022
Abstract

The magnitude of the UV-spectral change of chlorpromazine increases in the presence of increasing concentrations of alcohols or fatty acids and with increasing chain length. A maximum is reached with 14.0- or 16.0-fatty acids. The differential spectrum is still larger with unsaturated fatty acids, a maximum effect being obtained with one cis-double bond. The spectral change is abolished by chaotropic and enhanced by antichaotropic agents.

摘要

在醇类或脂肪酸浓度增加以及链长增加的情况下,氯丙嗪紫外光谱变化的幅度会增大。对于14.0或16.0脂肪酸会达到最大值。不饱和脂肪酸的差示光谱更大,对于含有一个顺式双键的脂肪酸可获得最大效应。光谱变化会被离液剂消除,而被抗离液剂增强。

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Interaction of chlorpromazine with organic solvents and fatty acids as studied by UV-spectrophotometry.通过紫外分光光度法研究氯丙嗪与有机溶剂和脂肪酸的相互作用。
Experientia. 1978 Aug 15;34(8):1047-9. doi: 10.1007/BF01915339.
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本文引用的文献

1
Micellar properties of drugs: properties of micellar aggregates of phenothiazines and their aqueous solutions.药物的胶束性质:吩噻嗪类药物的胶束聚集体性质及其水溶液性质
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2
Micellar properties of drugs: micellar and nonmicellar patterns of self-association of hydrophobic solutes of different molecular structures--monomer fraction, availability, and misuses of micellar hypothesis.药物的胶束性质:不同分子结构的疏水溶质的自缔合的胶束和非胶束模式——单体分数、可用性及胶束假说的误用
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3
Micellar properties of drugs: determination of molecular weight, size, and molecular interactions of drug micelles using the analytical ultracentrifuge.
药物的胶束性质:使用分析型超速离心机测定药物胶束的分子量、大小和分子间相互作用。
J Pharm Sci. 1974 Jun;63(6):981-7. doi: 10.1002/jps.2600630648.
4
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Chem Biol Interact. 1974 Mar;8(3):151-62. doi: 10.1016/0009-2797(74)90037-4.
5
Examination of phenothiazine-albumin interaction by ultraviolet difference spectrophotometry.通过紫外差示分光光度法检测吩噻嗪与白蛋白的相互作用。
Biochem Pharmacol. 1974 Mar 1;23(5):957-72. doi: 10.1016/0006-2952(74)90026-4.
6
Membrane lipids as intracellular binders of chlorpromazine and related drugs.
Chem Biol Interact. 1977 Mar;16(3):335-46. doi: 10.1016/0009-2797(77)90113-2.
7
Characterization of interactions of phenothiazines and related drugs with lipids by UV-spectrophotometry.
Psychopharmacol Commun. 1976;2(3):231-40.