Bryant B M, Wiltshaw E
Cancer Treat Rep. 1980 Apr-May;64(4-5):689-92.
Forty-eight patients with advanced soft tissue sarcoma were treated with a five-drug combination regimen consisting of vincristine, actinomycin D, and cyclophosphamide (Day 1) followed by doxorubicin and an infusion of methotrexate (Day 22). Thirty-seven of the 48 patients were fully evaluable. Of the 37 evaluable patients, two achieved a complete remission and three achieved a partial remission, with an overall response rate of 13.5%. These results compare unfavorably with previously reported series from this and other centers, and the regimen has now been superseded.
48例晚期软组织肉瘤患者接受了一种五药联合方案治疗，该方案包括长春新碱、放线菌素D和环磷酰胺（第1天），随后是阿霉素和甲氨蝶呤输注（第22天）。48例患者中有37例可进行全面评估。在这37例可评估患者中，2例实现完全缓解，3例实现部分缓解，总缓解率为13.5%。这些结果与该中心及其他中心之前报告的系列结果相比并不理想，该方案现已被取代。
