Goodman R L, Karsch F J
Endocrinology. 1980 Nov;107(5):1286-90. doi: 10.1210/endo-107-5-1286.
In sheep, physiological levels of estradiol and progesterone each suppress the pulses of LH characteristics of tonic LH secretion, but do so by completely different mechanisms. Estradiol treatment decreases LH pulse amplitude but not frequency and also inhibits the height of the LH peak resulting from the administration of gonadotropin-releasing hormone (GnRH). In contrast, progesterone decreases the frequency of LH pulses without reducing their amplitude or the response to exogenous GnRH. This suggests that progesterone suppresses tonic LH secretion by acting in the brain to decrease the frequency of GnRH pulses, while estradiol may suppress the response of the pituitary to GnRH and thereby decrease LH pulse amplitude.
在绵羊中，雌二醇和孕酮的生理水平各自抑制促黄体生成素（LH）呈脉冲式分泌的特性，但二者的作用机制完全不同。雌二醇处理会降低LH脉冲幅度，但不会降低频率，并且还会抑制因注射促性腺激素释放激素（GnRH）而产生的LH峰值高度。相比之下，孕酮会降低LH脉冲频率，而不降低其幅度或对外源GnRH的反应。这表明孕酮通过作用于大脑来降低GnRH脉冲频率，从而抑制LH的持续性分泌，而雌二醇可能会抑制垂体对GnRH的反应，进而降低LH脉冲幅度。
