Stankevich P B, Korablev M V
Farmakol Toksikol. 1978 Sep-Oct;41(5):586-90.
The TMTD does not change the secretory activity of the dogs' stomach with its one-time administration by mouth in doses of 0.5--10 mg/kg. With its multiple introduction (10 mg per kg once a day for a space of consecutive 30 days) the secretion of juice increases, while the pepsin content in the juice of dags diminishes. The DEDCS, EEDMDCA, TMTD and EBDCC (singly into the stomach in a dose of 1l5LD50 per kg) bring down the glycogen-forming and secretory function of the liver in rats and inhibit the propulsive activity of the intestines in mice, stimulated with 5-oxytryptophan. The mechanism of the intestinal motor activity inhibition is caused by the inhibition of oxytryptophandecarboxylase (CP 4.1.1.28) in the intestines of the animals with the DTCA derivatives.
以0.5 - 10毫克/千克的剂量经口一次性给予二硫化四甲基秋兰姆（TMTD），不会改变犬胃的分泌活动。多次给予（每天每千克10毫克，连续30天）会使胃液分泌增加，而犬胃液中的胃蛋白酶含量减少。二乙二硫代氨基甲酸钠（DEDCS）、乙撑双二硫代氨基甲酸二甲基二硫代氨基甲酰酯（EEDMDCA）、二硫化四甲基秋兰姆（TMTD）和乙撑双二氯甲酰亚胺（EBDCC）（每千克以1/5半数致死剂量单次注入胃内）会降低大鼠肝脏的糖原生成和分泌功能，并抑制用5 - 羟色氨酸刺激的小鼠肠道推进活动。动物肠道运动活动抑制的机制是由二硫代氨基甲酸盐衍生物使动物肠道中的羟色氨酸脱羧酶（CP 4.1.1.28）受到抑制所致。
