Nadeenko V G, Lenchenko V G, Genkina S B, Arkhipenko T A
Farmakol Toksikol. 1978 Sep-Oct;41(5):620-3.
Experients showed tungsten, molibdenum, copper and arsenic employed in doses producing no general toxic effect on the organism with their prolonged introduction to act adversely on the embryogenesis. Tungsten copper and arsenic were found to increase the embryonal lethality and tungsten and molebdenum to inhibit the processes of bones ossification in fetuses. The authors presume that the embryotoxic effect of the study elements is due to their direct action on the developing organism. Tungsten molibdenum and copper amass in the organism of test fetuses without being arrested in the placenta. A possible embryotoxic effect should be taken account of in chosing biogenic doses of trace elements.
实验表明，长期引入钨、钼、铜和砷，即使剂量不会对机体产生一般毒性作用，也会对胚胎发育产生不利影响。发现钨、铜和砷会增加胚胎致死率，钨和钼会抑制胎儿骨骼的骨化过程。作者推测，所研究元素的胚胎毒性作用是由于它们对发育中的机体的直接作用。钨、钼和铜在受试胎儿的机体内积累，而不会滞留在胎盘中。在选择微量元素的生物剂量时，应考虑可能的胚胎毒性作用。
