Parlapiano C, Vincentelli G M
Minerva Med. 1980 Sep 8;71(32):2265-72.
After examining the most recent findings on the physiopathology of the renin-angiotensin system, techniques are analysed for the determination of renin activity (PRA). These are still inadequate and imprecise, notwithstanding radioimmunological techniques and stress is laid on the importance of their standardisation. Analysis of the various forms of arterial hypertension shows that PRA measurement has clinical value only: 1) in nephrovascular hypertension; 2) in primary hyper-reninism; 3) in primary hypercorticosuprarenalism; 4) to back up an indication for bilateral nephrectomy in terminal nephropathies with uncontrollable pressure value. At the present time, however, it would appear that PRA does not have any clinical utility for the study of essential hypertension.
在研究了肾素-血管紧张素系统生理病理学的最新发现后，对测定肾素活性（PRA）的技术进行了分析。尽管有放射免疫技术，但这些技术仍然不够完善且不精确，强调了其标准化的重要性。对各种形式的动脉高血压的分析表明，PRA测量仅在以下情况具有临床价值：1）肾血管性高血压；2）原发性高肾素血症；3）原发性肾上腺皮质功能亢进；4）在终末期肾病且血压值无法控制时支持双侧肾切除术的指征。然而，目前看来，PRA在原发性高血压的研究中没有任何临床用途。
