Ferrero E, Casale G, Ciaponi A
Minerva Med. 1980 Sep 22;71(35):2489-96.
Seven aged subjects (mean age 78,5 years) and seven young controls (mean age 23,8 years), all nondiabetics and non-obese, were given intravenous injections of glucose, glucose and arginine, tolbutamide, tolbutamide and glucagon at 30 minutes intervals in order to determine the maximum insulin-secretory capacity of their pancreatic beta-islet cells after intensive stimulation. The response iun the elderly group was less prompt and quantitatively smaller at all stage of the test, but the beta-cells both in aged and in young subjects showed no evidence of exhaustion.
七名老年受试者（平均年龄78.5岁）和七名年轻对照者（平均年龄23.8岁），均为非糖尿病且非肥胖者，每隔30分钟静脉注射葡萄糖、葡萄糖加精氨酸、甲苯磺丁脲、甲苯磺丁脲加胰高血糖素，以测定其胰腺β胰岛细胞在强烈刺激后的最大胰岛素分泌能力。老年组在测试的各个阶段反应均较迟缓且量值较小，但老年和年轻受试者的β细胞均未显示出耗竭迹象。
