Martinand A, Lardoux H, Corvol P, Milliez P
Nouv Presse Med. 1980 Sep 27;9(35):2565-8.
The effects of labetalol, an alpha- and beta-adrenoceptor blocking drug, on blood pressure, heart rate, plasma renin activity (PRA) and plasma aldosterone were studied in 17 adult patients with essential hypertension. Following a total dose of 1 g labetalol administered over a 48-hour period, there was a rapid and significant fall in systolic and diastolic BP averaging 16,5 +/- 7,9%/14,8 +/- 7,5% respectively supine, 18,7 +/- 8,3%/17,8 +/- 7,2% standing and 23,9 +/- 7,1%/16,8 +/- 10,3% after moderate exercise; 24 hours after labetalol was discontinued, the BP had gone up but was still below pretreatment values. Bradycardia remained slight throughout. During treatment a significant decrease in PRA (mean : 45%) was observed in all patients and found to correlate in standing position with changes in standing and post-exercise mean arterial pressure. There was no significant changes in plasma aldosterone. Side-effects were mild and limited to tingling of the scalp in 5 patients. No clinical symptoms of postural hypotension were recorded.
对17例原发性高血压成年患者研究了α、β肾上腺素能受体阻滞剂拉贝洛尔对血压、心率、血浆肾素活性（PRA）及血浆醛固酮的影响。在48小时内给予总量1g拉贝洛尔后，仰卧位收缩压和舒张压迅速且显著下降，平均分别下降16.5±7.9%/14.8±7.5%，站立位下降18.7±8.3%/17.8±7.2%，中度运动后下降23.9±7.1%/16.8±10.3%；停用拉贝洛尔24小时后，血压有所回升但仍低于治疗前值。心动过缓始终轻微。治疗期间，所有患者的PRA均显著降低（平均降低45%），且发现站立位时PRA变化与站立位及运动后平均动脉压变化相关。血浆醛固酮无显著变化。副作用轻微，仅5例患者出现头皮刺痛。未记录到体位性低血压的临床症状。
