Lutz D, Krieger O, Nowotny H, Waldner R
Wien Klin Wochenschr. 1980 Aug 1;92(15):544-50.
So-called "Philadelphia-positive acute leukaemias" require varied therapeutic management. Additional chromosome anomalies together with Ph1 indicate an acute transformation of a Philadelphia-positive disease, requiring "non-myelotoxic" treatment and new therapeutic approaches. By contrast, "de novo" acute leukaemias with a Ph1-positive karyotype should be treated with intensive chemotherapy for the induction and maintainance of remission.
所谓的“费城染色体阳性急性白血病”需要不同的治疗方案。除费城染色体1（Ph1）外的其他染色体异常表明费城染色体阳性疾病发生了急性转化，需要“非骨髓毒性”治疗和新的治疗方法。相比之下，具有Ph1阳性核型的“原发性”急性白血病应以强化化疗进行诱导和维持缓解治疗。
