Bloch K, Daturi S, Tommasini R
Acta Endocrinol Suppl (Copenh). 1980;239:23-5.
This paper contains the results of further investigation on the possible extrapancreatic activity of glipizide. An in vitro method, using isolated rat diaphragm was selected. Muscle uptake of C14 glucose and output of labelled CO2, were measured. Insulin was used as the reference substance. The results of our experiments indicate that there is a qualitative difference in the effects of the two experimental situations. However, from these findings it may be assumed that glipizide facilitates the uptake and metabolism of glucose in muscle, thus demonstrating an extrapancreatic effect, which contributes to the hypoglycemic activity of the drug.
本文包含了对格列吡嗪可能存在的胰腺外活性的进一步研究结果。我们选择了一种使用分离的大鼠膈肌的体外方法。测量了肌肉对C14葡萄糖的摄取以及标记二氧化碳的输出。胰岛素用作参考物质。我们的实验结果表明，两种实验情况的效果存在质的差异。然而，从这些发现可以推测，格列吡嗪促进了肌肉中葡萄糖的摄取和代谢，从而证明了一种胰腺外效应，这有助于该药物的降血糖活性。
