肝线粒体后成分（S-9）对苯并[a]芘和二甲基亚硝胺的代谢活性。
Metabolizing activities of postmitochondrial liver fractions (S-9) on benzo[a]pyrene and dimethylnitrosamine.
作者信息
Teichmann B, Butschak G, Scheunig G, Köhler S
出版信息
Arch Toxicol Suppl. 1980;4:77-80. doi: 10.1007/978-3-642-67729-8_19.
The mutagenic activity of the carcinogens benz[a]pyrene and dimethylinitrosamine after being metabolised by postmitochondrial liver fractions (S-9) from rats, Syrian hamsters and rabbits was estimated in the Ames' test. The liver donors were pretreated with phenobarbital, 3-methylcholanthrene, PCB (Delor 106) or peanut oil. Parallel to the mutagenicity tests, enzymes of S-9 such as dimethylnitrosamine demethylase and aryl hydrocarbon hydroxylase were estimated and their activity evaluated with reference to the results of the Ames' test.
在艾姆斯试验中，评估了大鼠、叙利亚仓鼠和兔子的线粒体后肝组分（S-9）代谢致癌物苯并[a]芘和二甲基亚硝胺后的致突变活性。肝脏供体用苯巴比妥、3-甲基胆蒽、多氯联苯（De lor 106）或花生油进行预处理。与致突变性试验同时进行的是，对S-9的二甲基亚硝胺脱甲基酶和芳烃羟化酶等酶进行了测定，并参照艾姆斯试验的结果对其活性进行了评估。
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