Schulmannová J, Hála K, Hraba T
Folia Biol (Praha). 1978;24(4):270-80.
Tolerance to alloantigens of the A and B systems in chickens has been induced by multiple injections of RBC and tested by the elimination of 51Cr-labelled RBC of the same specificity. Three doses consisting of at least 108 RBC each in the B system and 107 RBC in the A system were needed to induce tolerance in newly hatched chicks. Futhermore, it was found that large doses, 109 RBC, in both systems induced tolerance in 100% of week-old and 50% of 14-day-old chickens. With doses of 109 RBC, tolerance to the B antigen disappeared at 8 days in the absence of RBC, whereas in the case of the A antigen it disappeared after more than 50 days, and with the 107 cell doses after 35 days. The elimination of A-incompatible RBC was proportional to the amount of anti-A antibodies present in the recipient's circulation, whereas a minimal amount of antibodies was capable of considerably accelerating the elimination of B-incompatible RBC.
通过多次注射红细胞诱导鸡对A和B系统同种异体抗原产生耐受性，并通过消除具有相同特异性的51Cr标记红细胞来进行检测。在B系统中，需要三次注射，每次至少108个红细胞，在A系统中需要107个红细胞，才能诱导新孵出的雏鸡产生耐受性。此外，还发现，在两个系统中注射大剂量（109个红细胞）可使100%的一周龄鸡和50%的14日龄鸡产生耐受性。注射109个红细胞剂量时，在没有红细胞的情况下，对B抗原的耐受性在8天时消失，而对于A抗原，在50多天后消失，注射107个细胞剂量时，在35天后消失。消除与A不相容的红细胞与受体循环中存在的抗A抗体量成正比，而极少量的抗体就能显著加速消除与B不相容的红细胞。
