非甾体抗炎药在癌症疼痛治疗中的应用。
Use of non-steroidal anti-inflammatory drugs in the treatment of pain in cancer.
作者信息
Ventafridda V, Fochi C, De Conno D, Sganzerla E
出版信息
Br J Clin Pharmacol. 1980 Oct;10 Suppl 2(Suppl 2):343S-346S. doi: 10.1111/j.1365-2125.1980.tb01820.x.
Abstract
1 Prostaglandins may precipitate or exacerbate pain and they may be produced by several tumours. 2 Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin synthesis and may also inhibit bone metastases and enhance immune responses. 3 NSAIDs alone or in association with narcotics or psychotropics may not only afford the best pain relief in neoplastic disease, but also modify the progress of the tumour. 4 The effect of NSAIDs on the gastrointestinal tract is generally adverse.
摘要
前列腺素可能会引发或加剧疼痛，且多种肿瘤都可能产生前列腺素。
非甾体抗炎药（NSAIDs）可抑制前列腺素的合成，还可能抑制骨转移并增强免疫反应。
单独使用NSAIDs或与麻醉药或精神药物联合使用，不仅可以在肿瘤疾病中提供最佳的疼痛缓解效果，还可能改变肿瘤的进展。
NSAIDs对胃肠道的影响通常是不利的。
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