Persson C G
Eur J Respir Dis Suppl. 1980;109:7-16.
Xanthines, best represented by theophylline, constitute a pharmacological principle of considerable age and importance in the treatment of asthma. Historical aspects of xanthines, effects of these compounds in the lung, and xanthine drug research are briefly reviewed. Data are presented on the active metabolite of theophylline, on relaxant effects of theophylline in large and small human respiratory airways, and on anti-edema effects of theophylline.
以茶碱为最佳代表的黄嘌呤类药物，在哮喘治疗中是一种历史悠久且极为重要的药理原理。本文简要回顾了黄嘌呤类药物的历史、这些化合物在肺部的作用以及黄嘌呤类药物的研究情况。文中还给出了关于茶碱活性代谢物的数据、茶碱对人类大小呼吸道的舒张作用数据以及茶碱的抗水肿作用数据。
