Schwetz B A, Rao K S, Park C N
J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):81-98.
Studies of reproductive capacity in rodents have been conducted for decades using a design which has had little refinement over the years. Most commonly, one or two litters from each of one through three generations are raised. The variability between studies, generations, groups, and animals often precludes the resolution of subtle toxicologic effects on reproductive parameters. Nonreproductive parameters yield more reliable data than reproductive parameters. Changes in design and additions to the protocol which will provide additional data are discussed. These include semen evaluation and the use of larger group sizes in reproduction studies.
几十年来，一直在使用一种多年来几乎没有改进的设计对啮齿动物的生殖能力进行研究。最常见的是，饲养一到三代中每一代的一到两窝幼崽。不同研究、代际、组和动物之间的变异性常常使得难以分辨对生殖参数的细微毒理学影响。非生殖参数比生殖参数能产生更可靠的数据。文中讨论了设计的改变和方案的补充，这些将提供更多数据。其中包括精液评估以及在生殖研究中使用更大的样本量。
