Saxén L, Karkinen-Jääskeläinen M
Ontogenez. 1980;11(5):451-66.
Morphogenetic cell interactions are considered during different periods of embryogenesis. The evidence is given which established that the determination of cells of the early mammalian embryos appeared to be due to their position and relations with the other cells. Morphogenetic cell interactions are heterogenous by their biological importance: there are both directive and permissive interactions. The cells might be multipotent and choose one of many paths of development what requires directive interactions, or they might be already "canalized" in a certain type of differentiation and their development requires, mainly, permissive interactions. Possible mechanisms of transmission of the morphogenetic stimuli to the reacting cells are analyzed.
在胚胎发生的不同阶段，会对形态发生细胞间的相互作用进行研究。文中给出的证据表明，早期哺乳动物胚胎细胞的分化似乎取决于它们的位置以及与其他细胞的关系。形态发生细胞间的相互作用在生物学重要性方面具有异质性：既有指导性相互作用，也有允许性相互作用。细胞可能具有多能性，并选择多种发育途径中的一种，这需要指导性相互作用；或者它们可能已经在某种分化类型中“定型”，其发育主要需要允许性相互作用。文中还分析了形态发生刺激传递到反应细胞的可能机制。
