[Age-related changes in splenic lymphocyte migration in mice].

Age changes of distribution of the labelled mouse lymphocytes in the organs of syngeneic recipients were followed. The changes were shown to concern both the circulating lymphocytes and their environment, the latter having suffered greater changes. On the contrary, changes in the lymphocytes played the leading role in this process in the autoimmune mice NZB. The disturbances described resulted in the decrease of tropism of the migrating lymphocytes to the lymphoid organs (homing) what might be one of the causes of decrease of immunological reactivity upon senescence.