Populaire P, Decouvelaere B, Renard A, Pasquier P
Pathol Biol (Paris). 1980 Nov;28(9):621-4.
Secnidazole, a derivative of 5-nitro imidazole exhibits trichomonacid, amoebicid and antimicrobial properties; it has been studied in view of its biological fate in healthy volunteers (man and woman) comparatively with tinidazole. Both products were administered orally to the same volunteers at the single dose level of 2 g. The seric concentrations and the pharmacokinetic profile were determined up to the 72nd hour after drug administration. The whole urinary excretion (unchanged product + metabolites) during the same period was determined in percent of the administered dose level. Secnidazole is particularly different from tinidazole owing to its slower blood clearance. The apparent average half-life in the ten volunteers (5 men and 5 women) is about 17 hours for secnidazole and 13 hours for tinidazole. However, for both drugs, a difference between men and women was demonstrated: in female volunteers, the decrease in blood concentrations occurs a little quicker than in male volunteers. Regarding urinary excretion, it is also a little greater in female volunteers than in male volunteers.
塞克硝唑是5-硝基咪唑的衍生物，具有抗滴虫、抗阿米巴和抗菌特性；已针对其在健康志愿者（男性和女性）体内的生物转归与替硝唑进行了比较研究。两种药物均以2克的单剂量水平口服给予相同的志愿者。在给药后72小时内测定血清浓度和药代动力学曲线。同时测定同一时期内整个尿液排泄量（原形药物+代谢物）占给药剂量水平的百分比。塞克硝唑与替硝唑有显著差异，因为其血液清除较慢。在十名志愿者（5名男性和5名女性）中，塞克硝唑的表观平均半衰期约为17小时，替硝唑为13小时。然而，对于两种药物，均显示出男性和女性之间的差异：在女性志愿者中，血药浓度下降比男性志愿者略快。关于尿液排泄，女性志愿者的排泄量也比男性志愿者略多。
