Ziegler J, Muggia F M
Recent Results Cancer Res. 1980;74:312-5. doi: 10.1007/978-3-642-81488-4_38.
Long-term sequelae of therapy of neoplastic disease have become an important topic, since many patients exposed to anticancer drugs will have prolonged survival. The advances which have been made in the treatment of pediatric malignancies, in fact, give particular relevance to a study of these complications. Moreover, clues as to the mechanism of action and molecular pharmacology of these agents may emerge from such studies. Herein we review both the specific organ dysfunction and the generalized effects which may become apparent as late consequences of chemotherapy.
肿瘤疾病治疗的长期后遗症已成为一个重要课题，因为许多接受抗癌药物治疗的患者生存期会延长。事实上，小儿恶性肿瘤治疗方面取得的进展使得对这些并发症的研究尤为重要。此外，这类研究可能会揭示这些药物的作用机制和分子药理学线索。在此，我们综述了化疗后期可能出现的特定器官功能障碍和全身性影响。
