Puigdollers J M, Serna G R, Hernandez del Rey I, Barruffet M T, Torroella J J
Respiration. 1980;40(3):142-9. doi: 10.1159/000194264.
The concentrations of secretory immunoglobulins in the saliva, and of immunoglobulin in the serum, have been measured by the radial immunodiffusion method in 12 healthy volunteers, before and after oral administration of Broncho-Vaxom which is a lysate of bacteria that usually cause infection in the upper respiratory tract. The mean concentration of secretory IgA in the saliva was increased by over 100% after the 10-day administration of the product. This increase was statistically significant between the 20th and 33rd day after the beginning of the treatment (p < 0.05). It fell to a normal level after a month in 4 subjects who received one treatment course only. In 8 subjects who received a second treatment course beginning 1 month after termination of the first course, the high concentration of IgAs in the saliva persisted for at least 3 months. A significant increase in the serum concentrations of IgG of about 50% and of IgM of at least 100% above the initial level was observed in the treated subjects in the time between day 35 and 5 months after the beginning of the experiment (p < 0.05).
采用放射免疫扩散法，对12名健康志愿者口服Broncho-Vaxom（一种通常引起上呼吸道感染的细菌裂解物）前后唾液中分泌型免疫球蛋白和血清中免疫球蛋白的浓度进行了测定。在服用该产品10天后，唾液中分泌型IgA的平均浓度增加了100%以上。这种增加在治疗开始后的第20天至第33天之间具有统计学意义（p<0.05）。仅接受一个疗程治疗的4名受试者在一个月后降至正常水平。在8名在第一个疗程结束后1个月开始接受第二个疗程治疗的受试者中，唾液中高浓度的IgA持续了至少3个月。在实验开始后的第35天至5个月期间，治疗组受试者血清中IgG浓度显著增加约50%，IgM浓度至少比初始水平增加100%（p<0.05）。
