Chlebowsky H O, Zielke E
Tropenmed Parasitol. 1980 Sep;31(3):339-44.
464 persons of whom 189 proved to be infected with microfilariae of Wuchereria bancrofti and/or Onchocerca volvulus were examined for adverse reactions due to diethylcarbamazine, which was administered during a filariasis control campaign. Persons older than 20 years of age were significantly more affected than younger persons and men showed distinctly more side effects than women. The most frequent complaints were skin reactions followed by gastrointestinal complications. The significantly highest rate of adverse reactions was observed in persons being infected with microfilariae of O. volvulus, whereas no significant difference was registered between side effect rates of bancroftian microfilaria carriers and non-infected persons. It is concluded that in areas where both filarial species are endemic, infections with O. volvulus are a limiting factor for the control of bancroftian filariasis by means of mass treatment with diethylcarbamazine.
在一次丝虫病防治运动中，对464人进行了检查，以了解乙胺嗪治疗引起的不良反应，其中189人被证实感染了班氏吴策线虫和/或盘尾丝虫的微丝蚴。20岁以上的人比年轻人受影响的程度明显更高，男性出现的副作用明显多于女性。最常见的不适是皮肤反应，其次是胃肠道并发症。盘尾丝虫微丝蚴感染者的不良反应发生率显著最高，而班氏微丝蚴携带者和未感染者的副作用发生率之间没有显著差异。得出的结论是，在两种丝虫均为地方病的地区，盘尾丝虫感染是通过乙胺嗪群体治疗控制班氏丝虫病的一个限制因素。
