4至8个大气压的高压对小鼠乙醇麻醉的拮抗作用。
Antagonism of ethanol narcosis in mice by hyperbaric pressures of 4-8 atmospheres.
作者信息
Alkana R L, Malcolm R D
出版信息
Alcohol Clin Exp Res. 1980 Oct;4(4):350-3. doi: 10.1111/j.1530-0277.1980.tb04830.x.
Abstract
Hyperbaric treatment with 100% oxygen or oxygen-helium mixtures at 4-8 atmospheres absolute significantly reduced ethanol sleep-time and increased wake-up blood ethanol concentrations in C57 mice. The results indicate that the antagonism does not result from direct effects of oxygen nor from enhanced ethanol elimination, but appears to involve a direct effect of hyper-baric treatment.
摘要
在绝对压力为4至8个大气压的条件下，用100%氧气或氧氦混合气体进行高压治疗，可显著缩短C57小鼠的乙醇睡眠时间，并提高清醒时的血液乙醇浓度。结果表明，这种拮抗作用并非由氧气的直接作用或乙醇消除增强所致，而是似乎涉及高压治疗的直接作用。
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