Dieterlen P, Desjeux J F, Giraud M, Villard S, Lestradet H
Arch Fr Pediatr. 1980;37 Suppl 2:XXXIX-XLII.
Three groups of ten similar obese children were infused with one of three protocols. Protocol I glucose only (1.15 mM/min/m2). protocol II, glucose, insulin (42 mM/min/m2). Protocol III, glucose insulin, propanolol (0.04 mg/min/m2) adrenalin (3 micrograms/min/m2). Eighteen newly diagnosed diabetic children without acidosis received glucose according to protocol II. Thirteen normal adults (controls) received glucose infusion according to protocol I. Protocols I and II were well tolerated and gave consistent results but Protocol III was not well tolerated and did not give interpretable results. In obese children steady state blood glucose levels are significantly higher than in controls but this difference was only moderate (8.8 + 0.7 mM, against 6.6 +/- 0.4 mM for protocol I). There was no difference in insulin levels. In diabetic children the steady state was more rarely obtained after a 120 min infusion and blood glucose levels were higher than in the controls or in obese children.
将三组每组十名相似的肥胖儿童按照三种方案之一进行输注。方案I仅输注葡萄糖（1.15毫摩尔/分钟/平方米）。方案II输注葡萄糖、胰岛素（42毫摩尔/分钟/平方米）。方案III输注葡萄糖、胰岛素、普萘洛尔（0.04毫克/分钟/平方米）、肾上腺素（3微克/分钟/平方米）。18名新诊断的无酸中毒糖尿病儿童按照方案II输注葡萄糖。13名正常成年人（对照组）按照方案I进行葡萄糖输注。方案I和方案II耐受性良好且结果一致，但方案III耐受性不佳且未得出可解释的结果。肥胖儿童的稳态血糖水平显著高于对照组，但这种差异仅为中等程度（8.8±0.7毫摩尔，方案I对照组为6.6±0.4毫摩尔）。胰岛素水平无差异。糖尿病儿童在120分钟输注后更难达到稳态，且血糖水平高于对照组或肥胖儿童。
