Cottereau M J, Tanios A, Chamballon O
Encephale. 1980;6(3):209-26.
Alcoholism and depression have always been in intricated. A lot of studies try presently to precise this relation:--Clinical studies about episodic alcoholism.--Genetical studies showing a debatable relation between alcoholism and unipolar depression.--Biological studies essentialy attesting a depressive action of ethanol among the serotoninergic system: ethanol would deviate the serotonin metabolism. Likewise it would induce a depletion of catecholamines in the brain. More, biochemical researches point out an inheritance of ethanol preference which would be correlated with a decrease of the brain level of serotonin. Is is a genetical transmission of alcoholism: these perturbations could manifest themselves by the ethanol dependence, or by depressive trends?
酒精中毒与抑郁症一直错综复杂。目前许多研究试图明确这种关系：——关于发作性酒精中毒的临床研究。——遗传学研究表明酒精中毒与单相抑郁症之间存在有争议的关系。——生物学研究主要证明乙醇在血清素能系统中具有抑郁作用：乙醇会使血清素代谢偏离正常。同样，它会导致大脑中儿茶酚胺的消耗。此外，生化研究指出乙醇偏好具有遗传性，这与大脑血清素水平的降低有关。这是酒精中毒的遗传传递：这些紊乱是会通过对乙醇的依赖表现出来，还是通过抑郁倾向表现出来呢？
