Mizuta K, Itaya K
Nihon Yakurigaku Zasshi. 1978 May;74(4):517-24.
The inhibitory effects of gamma-oryzanol and atropine on the gastric secretion were studied using insulin and 2-deoxy-D-glucose as vagal stimulants. Pretreatment with gamma-oryzanol (100 mg/kg, s.c., once daily x 5) depressed the gastric secretion stimulated by insulin or 2-deoxy-D-glucose, but the potency was less than that with atropine (10 mg/kg, s.c.). gamma-Oryzanol had no effect on decrease in the serum glucose level or on increase in the gastrin level induced by insulin injection, while atropine enhanced these responses. From these results, it is considered that the inhibitory action of gamma-oryzanol on gastric secretion may be due to depression of the vagus system but the mode of action is different from that of atropine.
使用胰岛素和2-脱氧-D-葡萄糖作为迷走神经刺激剂，研究了γ-谷维素和阿托品对胃液分泌的抑制作用。γ-谷维素预处理（100mg/kg，皮下注射，每日一次，共5次）可抑制胰岛素或2-脱氧-D-葡萄糖刺激引起的胃液分泌，但其效力低于阿托品（10mg/kg，皮下注射）。γ-谷维素对胰岛素注射引起的血糖水平降低或胃泌素水平升高无影响，而阿托品增强了这些反应。从这些结果来看，γ-谷维素对胃液分泌的抑制作用可能是由于迷走神经系统的抑制，但作用方式与阿托品不同。
