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脊髓横断与慢肌球蛋白同工酶的出生后分化

Spinal transection and the postnatal differentiation of slow myosin isoenzymes.

作者信息

Margreth A, Dalla Libera L, Salviati G, Ischia N

出版信息

Muscle Nerve. 1980 Nov-Dec;3(6):483-6. doi: 10.1002/mus.880030604.

DOI:10.1002/mus.880030604
PMID:7005669
Abstract

Newborn rats underwent cordotomy, and the myosin composition of individual muscles was investigated 3 months postoperatively. The results indicate that, after cordotomy, the myosin composition in the extensor digitorum longus and tibialis anterior muscles is normal, whereas in the soleus muscle the myosin has catalytic and molecular properties intermediate between those of adult fast and slow myosin. Together with histochemical data these results indicate that spinal transection causes a developmental arrest in the soleus muscle, at a stage corresponding to a mixed fiber population.

摘要

新生大鼠接受了脊髓切断术,并在术后3个月研究了各个肌肉的肌球蛋白组成。结果表明,脊髓切断术后,趾长伸肌和胫骨前肌的肌球蛋白组成正常,而比目鱼肌的肌球蛋白具有介于成年快肌和慢肌肌球蛋白之间的催化和分子特性。这些结果与组织化学数据一起表明,脊髓横断导致比目鱼肌在一个与混合纤维群体相对应的阶段出现发育停滞。

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Spinal transection and the postnatal differentiation of slow myosin isoenzymes.脊髓横断与慢肌球蛋白同工酶的出生后分化
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J Cell Biol. 1985 Jan;100(1):161-74. doi: 10.1083/jcb.100.1.161.
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J Muscle Res Cell Motil. 1988 Jun;9(3):219-32. doi: 10.1007/BF01773892.