Makowski L
Prog Clin Biol Res. 1980;40:233-58.
The principles of structural design and the bonding properties of structural proteins form a basis for the study of virus assembly. Virus coat proteins are designed specifically to interact with one another and with the viral nucleic acid to form a stable virus particle. The process of assembly is controlled by the switching of protein subunit conformation, which can alter the binding properties of the subunits. The self-assembly processes of several simple viruses in vitro have significantly different rates of assembly and specificities for their viral nucleic acid. It is possible that many viruses have multiple pathways for assembly, each pathway exhibiting somewhat different characteristics but all resulting in identical infectious virus particles.
结构设计原理和结构蛋白的结合特性构成了病毒组装研究的基础。病毒衣壳蛋白经过专门设计，可相互作用并与病毒核酸相互作用，以形成稳定的病毒颗粒。组装过程由蛋白质亚基构象的转换控制，这可以改变亚基的结合特性。几种简单病毒在体外的自组装过程具有明显不同的组装速率和对其病毒核酸的特异性。许多病毒可能有多种组装途径，每条途径表现出略有不同的特征，但都产生相同的感染性病毒颗粒。
