Ost L, Groth C G, Lindholm B, Lundgren G, Magnusson G, Tillegård E
Transplantation. 1980 Nov;30(5):339-40. doi: 10.1097/00007890-198011000-00006.
Between 1971 and 1977, 34 patients aged 60 years and above were treated with cadaveric renal transplantation in Stockholm. The survival figures were nearly the same as for patients of the same age group that had undergone long-term dialysis, with 2-year survival rates of 49 and 45%, respectively. Comparison with a younger group of transplant patients, ages 16 to 49, showed poorer patient and graft survival figures for the older patients, with 49 and 38%, respectively, after 2 years against 70 and 56% for the younger group. Complications were more frequent among the older patients, especially in regard to serious infections, heart conditions, and steroid diabetes. Irreversible rejection, on the other hand, was less common in the older group. On the basis of these findings, we intend continuing to offer renal transplantation to patients of 60 years and above. It would, moreover, seem worthwhile to try to reduce the dose of prednisolone in these patients.
1971年至1977年间,斯德哥尔摩有34名60岁及以上的患者接受了尸体肾移植治疗。其存活率与接受长期透析的同年龄组患者几乎相同,2年存活率分别为49%和45%。与年龄在16至49岁的较年轻移植患者组相比,老年患者的患者和移植物存活率较低,2年后分别为49%和38%,而较年轻组为70%和56%。老年患者的并发症更为频繁,尤其是在严重感染、心脏疾病和类固醇糖尿病方面。另一方面,不可逆排斥在老年组中较少见。基于这些发现,我们打算继续为60岁及以上的患者提供肾移植。此外,尝试降低这些患者的泼尼松龙剂量似乎是值得的。