Husby G, Tung K S, Williams R C
Am J Med. 1981 Jan;70(1):31-8. doi: 10.1016/0002-9343(81)90408-3.
Five patients with interstitial nephritis who presented with a variety of clinical profiles were studied with particular emphasis on documentation of the cellular types of potentially immunocompetent lymphocytes and mononuclear cells present within interstitial renal infiltrates. Immunohistologic studies coupled with conventional light and electron microscopic observations indicated that most mononuclear cells making up renal interstitial infiltrates were T cells. Some chronic inflammatory cell foci within renal interstitium were characterized by clusters of Ia antigen-positive T cells considered to be markers for activated lymphocytes. B cells were present in very small proportions (5 percent or less). The profile of immunocompetent cells present in lesions of interstitial nephritis suggests a major role for cell-mediated immunity in this disorder. Increase in tissue lymphocytes of the T gamma subclass with receptors for the Fc portion of immunoglobulin G (IgG) also suggests local activation of intrinsic suppressor cell mechanisms.
对5例呈现出各种临床特征的间质性肾炎患者进行了研究，特别着重记录肾间质浸润中潜在具有免疫活性的淋巴细胞和单核细胞的细胞类型。免疫组织学研究结合传统的光镜和电镜观察表明，构成肾间质浸润的大多数单核细胞是T细胞。肾间质内的一些慢性炎性细胞灶以Ia抗原阳性T细胞簇为特征，这些T细胞被认为是活化淋巴细胞的标志物。B细胞的比例非常小（5%或更低）。间质性肾炎病变中存在的免疫活性细胞谱表明细胞介导的免疫在这种疾病中起主要作用。具有免疫球蛋白G（IgG）Fc段受体的Tγ亚类组织淋巴细胞增加也提示内在抑制细胞机制的局部活化。
