Köhler C, Chan-Palay V, Haglund L, Steinbusch H
Anat Embryol (Berl). 1980;160(2):121-9. doi: 10.1007/BF00301855.
The distribution of serotonin (5-hydroxytryptamine, 5HT) containing nerve terminals in the lateral entorhinal cortex (LEC) has been studied using antibodies against 5-HT in combination with fluorescence histochemistry. Thin, varicose, branching fibers were found to be distributed in a relatively even, diffuse pattern throughout all layers of the LEC. The largest amount of this type of 5HT innervation was in Layer I. This diffuse pattern of 5-HT terminals was supplemented by a dense network of 5HT terminals restricted to Layer III of a small (approximately 1 mm) strip of the LEC. The fibers in this layer were thicker and more convoluted and contained larger varicosities than fibers in any other layer. The existence of a distinct innervation by 5-HT terminals of only a small portion of the LEC demonstrates a hitherto unrecognized and important principle of heterogeneity in 5-HT innervation of cortex. It suggests that 5-5HT neurons in the raphe can selectively influence specific, narrow regions of the lateral perforant path system, which, in turn, affect the intrinsic hippocampal circuits.
利用抗5-羟色胺（5-HT）抗体结合荧光组织化学方法，对内侧嗅皮层（LEC）中含5-羟色胺（血清素，5HT）的神经终末分布进行了研究。发现细小、有膨体的分支纤维以相对均匀、弥散的方式分布于LEC的所有层中。这类5HT神经支配数量最多的是I层。这种5-HT终末的弥散模式还得到了一个局限于LEC一小条带（约1毫米）III层的5HT终末密集网络的补充。该层中的纤维比其他任何层中的纤维更粗、更卷曲，且含有更大的膨体。仅LEC的一小部分区域存在5-HT终末的独特神经支配，这表明在皮层5-HT神经支配中存在一个迄今未被认识到的重要异质性原则。这表明中缝核中的5-5HT神经元可以选择性地影响外侧穿通通路系统的特定、狭窄区域，进而影响海马的内在回路。
