Chalon J, Tang C K, Klein G S, Ramanathan S, Patel C, Turndorf H
Arch Pathol Lab Med. 1981 Jan;105(1):11-4.
Anesthesiologists normally discard the material routinely suctioned from the tracheal tube of patients under general endotracheal anesthesia. We preserved, and later examined microscopically, specimens from 10,621 patients. We found 11 cytologically abnormal smears from subjects with unsuspected pulmonary involvement, an incidence slightly more than 1:1,000. The accuracy of our method was assessed by calculation of the percent of abnormal smears obtained from patients with prediagnosed bronchogenic carcinomas: 40% when suctioned material was immediately spread on slides, and 67% when cellular concentration was achieved by mucolysis followed by filtration or centrifugation. Secretions normally discarded can reveal much information that would otherwise be missed. Our method may be useful if applied to patients at risk (heavy smokers, workers with asbestos, nitrosamine, or benzopyrine, miners of radioactive material, etc) who undergo general anesthesia for incidental surgery.
麻醉医生通常会丢弃在全身气管内麻醉下从患者气管导管中常规吸出的物质。我们保存了10621例患者的标本，并在之后进行了显微镜检查。我们从肺部未被怀疑有病变的受试者中发现了11份细胞学异常涂片，发病率略高于千分之一。通过计算从预先诊断为支气管源性癌的患者中获得的异常涂片百分比来评估我们方法的准确性：当吸出物立即涂在载玻片上时为40%，当通过粘液溶解后过滤或离心实现细胞浓缩时为67%。通常被丢弃的分泌物可能会揭示许多否则会被遗漏的信息。如果将我们的方法应用于因意外手术接受全身麻醉的高危患者（重度吸烟者、接触石棉、亚硝胺或苯并芘的工人、放射性物质矿工等），可能会很有用。
