系统性红斑狼疮的氟仑替唑治疗

Frentizole therapy in systemic lupus erythematosus.

作者信息

Sabharwal U K, Vaughan J H, Kaplan R A, Robinson C A, Curd J G

出版信息

Arthritis Rheum. 1980 Dec;23(12):1376-80. doi: 10.1002/art.1780231208.

Abstract

Seven corticosteroid dependent patients with active systemic lupus erythematosus (SLE) were given frentizole in order to assess its effect on their clinical manifestations. Three patients exhibited slight clinical improvement, 2 patients did not change, and 2 deteriorated. Five of the 7 patients developed subclinical and reversible liver damage related to frentizole. This study, although preliminary and uncontrolled, suggests that frentizole is of limited value in the management of patients with SLE.

摘要

为评估夫仑替唑对7例患有活动性系统性红斑狼疮（SLE）且依赖皮质类固醇的患者临床表现的影响，给予了他们夫仑替唑治疗。3例患者临床症状稍有改善，2例无变化，2例病情恶化。7例患者中有5例出现了与夫仑替唑相关的亚临床和可逆性肝损伤。这项研究虽然是初步且无对照的，但表明夫仑替唑在SLE患者的治疗中价值有限。