Antonaccio M J, Ferrone R A, Waugh M, Harris D, Rubin B
Hypertension. 1980 Nov-Dec;2(6):723-81. doi: 10.1161/01.hyp.2.6.723.
The relative roles of the sympathetic nervous system and renin-angiotensin system in the development of two-kidney renal hypertension were studied using four groups of rats: Group I = vehicle control; Group II = 6-OH-dopamine (2 weeks prior to renal clipping then weekly throughout the study); Group III = adrenal medullectomy plus vehicle; Group IV = 6-OH-dopamine plus adrenal medullectomy. Six weeks after clipping of a single renal artery, plasma renin activity (PRA) was comparably elevated in all groups. However, mean blood pressure (MBP) of Group II was lower than that of Group I controls (154.7 +/- 6.8 vs 197.3 +/- 6.6 mm Hg respectively). The MBP of Group III (207.0 +/- 5.2 mm Hg) was not different from that of Group I whereas in Group IV (134.2 +/- 18.0 mm Hg) it was markedly lower. All groups of rats were given a single dose of captopril (30 mg/kg p.o.) to inhibit the renin-angiotensin system. Despite differences in starting MBP, captopril caused similar reductions (38-50%) of MBP and increases in PRA in all groups. Similar results were obtained in two-kidney renal hypertensive rats with hypertension of 12 weeks' duration. It is concluded that the sympathetic nervous system does not contribute to the elevated PRA in two-kidney renal hypertensive rats but does contribute significantly to the development of hypertension in this model.
利用四组大鼠研究了交感神经系统和肾素 - 血管紧张素系统在二肾性肾高血压发生发展中的相对作用：第一组 = 赋形剂对照；第二组 = 6 - 羟基多巴胺（肾动脉夹闭前2周给药，然后在整个研究期间每周给药一次）；第三组 = 肾上腺髓质切除术加赋形剂；第四组 = 6 - 羟基多巴胺加肾上腺髓质切除术。单肾动脉夹闭6周后，所有组的血浆肾素活性（PRA）均同等程度升高。然而，第二组的平均血压（MBP）低于第一组对照（分别为154.7±6.8 mmHg和197.3±6.6 mmHg）。第三组的MBP（207.0±5.2 mmHg）与第一组无差异，而第四组（134.2±18.0 mmHg）则明显较低。给所有组大鼠单次口服卡托普利（30 mg/kg）以抑制肾素 - 血管紧张素系统。尽管起始MBP存在差异，但卡托普利在所有组中均使MBP产生相似程度的降低（38 - 50%）并使PRA升高。在病程为12周的二肾性肾高血压大鼠中也获得了类似结果。结论是，交感神经系统对二肾性肾高血压大鼠PRA升高无作用，但在该模型中对高血压的发生发展有显著作用。
