Abbas A K, James S L, Sher A
J Immunol. 1981 Mar;126(3):1022-4.
Skin-stage schistosomula of Schistosoma mansoni modified with 2,4,6-trinitrophenyl (TNP) induce primary anti-TNP plaque-forming cell (PFC) responses in normal mouse spleen cells in vitro. The PFC are TNP-specific, and the response is dependent on adherent cells and T lymphocytes. In contrast, comparably haptenated lung stage larvae are weakly or nonimmunogenic in this system, and their inability to stimulate anti-TNP PFC cannot be attributed to a toxic or suppressive effect. These observations suggest that maturation of schistosomula in vivo is accompanied by a decline in their immunogenicity, which, along with other adaptive mechanisms, may promote the survival of parasites in the host environment.
用2,4,6-三硝基苯基（TNP）修饰的曼氏血吸虫皮肤期童虫可在体外诱导正常小鼠脾细胞产生原发性抗TNP抗体形成细胞（PFC）反应。这些PFC具有TNP特异性，且该反应依赖于贴壁细胞和T淋巴细胞。相比之下，在该系统中，经类似半抗原化的肺期幼虫免疫原性较弱或无免疫原性，其无法刺激抗TNP PFC不能归因于毒性或抑制作用。这些观察结果表明，体内童虫的成熟伴随着其免疫原性的下降，这与其他适应性机制一起，可能促进寄生虫在宿主环境中的存活。
