Goodman R L, Knobil E
Neuroendocrinology. 1981 Jan;32(1):57-63. doi: 10.1159/000123130.
In the monkey, estradiol appears to exert both its negative and positive feedback actions on gonadotropin secretion primarily at the hypophysial level. In the rat, inhibitory and stimulatory effects of estradiol on the pituitary are also evident, but additional actions on the medial basal hypothalamus (MBH) and preoptic area must be postulated to fully account for the negative and positive feedback effects of estradiol in this species. The available evidence points to the MBH as a site for the negative feedback action of progesterone in the rat. In both species, progesterone probably acts in the central nervous system to block the positive feedback action of estradiol while the facilitation of luteinizing hormone release by this steroid appears to be at a hypophysial level.
在猴子中，雌二醇似乎主要在垂体水平对促性腺激素分泌发挥其负反馈和正反馈作用。在大鼠中，雌二醇对垂体的抑制和刺激作用也很明显，但必须假定其对内侧基底下丘脑（MBH）和视前区还有其他作用，才能充分解释雌二醇在该物种中的负反馈和正反馈作用。现有证据表明，MBH是大鼠体内孕酮负反馈作用的位点。在这两个物种中，孕酮可能在中枢神经系统中发挥作用，以阻断雌二醇的正反馈作用，而这种类固醇对促黄体生成素释放的促进作用似乎是在垂体水平。
