Daniels T E, Quadra-White C
Oral Surg Oral Med Oral Pathol. 1981 Jan;51(1):38-47. doi: 10.1016/0030-4220(81)90124-9.
We retrospectively analyzed direct immunofluorescence (DIF) findings from 130 cases of oral mucosal disease. The diagnosis of each case was based on history, clinical features, histopathology, and clinical follow-up. To avoid circular reasoning, we did not use the DIF results in forming the diagnoses. Our results indicate that the presence of characteristic fluorescent patterns produced by several DIF reagents can establish the diagnosis of the oral lesions of pemphigus and pemphigoid and strongly indicate the diagnoses of lichen planus and lupus erythematosus. The absence of these fluorescent patterns can help to rule out these conditions, thereby strengthening the diagnoses of other oral mucosal diseases. The results of DIF are sufficiently distinguishing to be routinely helpful as diagnostic criteria for chronic ulcerative diseases of the oral mucosa.
我们回顾性分析了130例口腔黏膜病患者的直接免疫荧光（DIF）检查结果。每例患者的诊断均基于病史、临床特征、组织病理学及临床随访情况。为避免循环论证，我们在进行诊断时未采用DIF结果。我们的结果表明，几种DIF试剂产生的特征性荧光模式的出现可确立天疱疮和类天疱疮口腔损害的诊断，并强烈提示扁平苔藓和红斑狼疮的诊断。这些荧光模式的缺失有助于排除这些疾病，从而强化其他口腔黏膜病的诊断。DIF结果具有足够的鉴别性，可作为口腔黏膜慢性溃疡性疾病的常规诊断标准。
