Moreau-Dubois M C, Cathala F, Brown P, Gajdusek D C
Rev Neurol (Paris). 1980;136(5):401-9.
We have tested the in vitro cellular fusing activity of brain suspensions from the following categories of patients: CJD (53 cases), Alzheimer (23 cases), and non-neurological controls (25 cases). CSF specimens were also available for 26 of the CJD patients. Our results show that 65-75 per cent of CJD brain specimens induce cell fusion but that this activity is only rarely reflected in matched CSF specimens. Among other types of degenerative neurological diseases, a sharp distinction appeared between familial Alzheimer disease, which caused fusion at nearly the same frequency as CJD, and sporadic Alzheimer disease, which was not significantly different from the non-neurological control specimens. The biological and clinical significance of these results are discussed.
克雅氏病（CJD，53例）、阿尔茨海默病（23例）以及非神经疾病对照者（25例）。26例CJD患者也有脑脊液（CSF）标本。我们的结果显示，65% - 75%的CJD脑标本可诱导细胞融合，但这种活性在匹配的CSF标本中很少体现。在其他类型的退行性神经疾病中，家族性阿尔茨海默病与CJD引起细胞融合的频率相近，而散发性阿尔茨海默病与非神经疾病对照标本无显著差异，二者之间存在明显区别。本文讨论了这些结果的生物学和临床意义。
