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氟桂利嗪用于静脉功能不全的双盲安慰剂对照研究。

Double-blind placebo-controlled studies with flunarizine in venous insufficiency.

作者信息

Roeckaerts F, Vanden Bussche G

出版信息

Angiology. 1980 Dec;31(12):833-45. doi: 10.1177/000331978003101204.

DOI:10.1177/000331978003101204
PMID:7008658
Abstract

In 4 placebo-controlled double-blind studies of patients suffering from venous insufficiency--defined as the presence of varicose veins combined with a range of subjective symptoms and presence of venous ulcers--flunarizine was statistically significantly superior to placebo in improving symptomatology, reducing the circumference of swollen lower legs and ankles, and increasing the speed of healing of venous ulcers. No side-effects were noted.

摘要

在4项针对患有静脉功能不全(定义为存在静脉曲张并伴有一系列主观症状以及静脉溃疡)患者的安慰剂对照双盲研究中,氟桂利嗪在改善症状、减小小腿和脚踝肿胀周长以及加快静脉溃疡愈合速度方面,在统计学上显著优于安慰剂。未观察到副作用。

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Double-blind placebo-controlled studies with flunarizine in venous insufficiency.氟桂利嗪用于静脉功能不全的双盲安慰剂对照研究。
Angiology. 1980 Dec;31(12):833-45. doi: 10.1177/000331978003101204.
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引用本文的文献

1
Intra-observer and inter-observer reliability of leg circumference measurement among six observers: a single blinded randomized trial.六名观察者之间腿部周长测量的观察者内和观察者间可靠性:一项单盲随机试验。
J Med Life. 2017 Jul-Sep;10(3):176-181.
2
Flunarizine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use.氟桂利嗪。其药效学和药代动力学特性及治疗用途综述。
Drugs. 1984 Jan;27(1):6-44. doi: 10.2165/00003495-198427010-00002.