Double-blind placebo-controlled studies with flunarizine in venous insufficiency.

In 4 placebo-controlled double-blind studies of patients suffering from venous insufficiency--defined as the presence of varicose veins combined with a range of subjective symptoms and presence of venous ulcers--flunarizine was statistically significantly superior to placebo in improving symptomatology, reducing the circumference of swollen lower legs and ankles, and increasing the speed of healing of venous ulcers. No side-effects were noted.