Landymore R W, Murphy D A, Kinley E, Parrott J, Sai O, Quirbi A A
Ann Thorac Surg. 1980 Dec;30(6):558-63. doi: 10.1016/s0003-4975(10)61730-4.
Twenty patients undergoing elective myocardial revascularization for coronary insufficiency were divided into two equal groups. In 10 patients, propranolol was discontinued 24 hours before operation while the remaining patients received propranolol until the day of operation. Plasma renin was elevated in the intensive care unit in the control group (p < 0.05) whereas patients receiving propranolol did not demonstrate significant elevation of plasma renin. Systemic vascular resistance was elevated in both groups in the intensive care unit (p < 0.05) and was associated with hypertension as defined by a blood pressure of greater than or equal to 160/100 mm Hg in 80% of the control patients and 70% of patients receiving propranolol. We conclude from this study that renin metabolism does not contribute significantly to the production of hypertension following coronary artery operation.
20例因冠状动脉供血不足而接受择期心肌血运重建术的患者被平均分为两组。10例患者在手术前24小时停用普萘洛尔，其余患者则一直服用普萘洛尔直至手术当天。在重症监护病房，对照组患者的血浆肾素水平升高（p<0.05），而服用普萘洛尔的患者血浆肾素水平未出现显著升高。在重症监护病房，两组患者的全身血管阻力均升高（p<0.05），且与高血压相关，对照组80%的患者和服用普萘洛尔的患者中70%的患者血压大于或等于160/100 mmHg即被定义为高血压。我们从这项研究得出结论，肾素代谢对冠状动脉手术后高血压的产生没有显著影响。
