吉非贝齐对血脂水平的影响。
Effect of gemfibrozil on serum lipid levels.
作者信息
Dahlén G, Gillnäs T, Børresen A L, Berg K, Ericson C
出版信息
Artery. 1980;7(3):224-31.
A short term investigation of the effect of Gemfibrozil in 1200 mg daily doses has been carried out in a group of 20 Swedish males, 9 Lp[a+] and 11 Lp[a-]. The effect of 8 weeks of treatment upon serum lipids resembled those found in previous trials, with a significant decrease in serum total cholesterol. In this series, even VLDL cholesterol and apoB levels decreased significantly. With the apparent exception of HDL cholesterol, there was no suggestion that Lp[a+] individuals responded less well to treatment than did Lp[a-] individuals.
对一组20名瑞典男性（9名Lp[a+]和11名Lp[a-]）进行了一项短期研究，以探讨每日服用1200毫克吉非贝齐的效果。8周治疗对血脂的影响与先前试验中发现的情况相似，血清总胆固醇显著降低。在该系列研究中，甚至极低密度脂蛋白胆固醇和载脂蛋白B水平也显著下降。除了高密度脂蛋白胆固醇明显例外，没有迹象表明Lp[a+]个体对治疗的反应不如Lp[a-]个体。
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