Kinetics of drug interactions in the treatment of epilepsy.
作者信息
van der Kleijn E, Vree T, Guelen P, Schobten F, Westenberg H, Knop H
出版信息
Int J Clin Pharmacol Biopharm. 1978 Oct;16(10):467-73.
PMID:700910
Abstract
The interactions of antiepileptic drugs in multiple drug treatment have been discussed. Although some combinations may lead to predictable increase or decrease of clearance of the respective drugs, most combinations will individually lead to a reduced predictability. Monitoring plasma concentrations may lead to adaptations of the choice of the drug and of the dosage regimen. Also physiological conditions control the individual clearance of antiepileptic drugs.
摘要
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